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馮芳,藥物分析學博士,教授、博士生導師;教育部藥物質(zhì)量與安全預警重點實驗室學術(shù)帶頭人。2000-2001年日本歧阜藥科大學藥學部高級訪問學者。
研究方向藥物質(zhì)量研究與評價
研究內(nèi)容藥物質(zhì)量分析方法建立研究、藥物體內(nèi)過程分析研究、手性藥物拆分及體內(nèi)立體選擇性藥代動力學研究、中藥(復方)藥效物質(zhì)基礎研究。
學術(shù)兼職國家藥典委員會委員、國家獸藥典委員會委員、國家藥監(jiān)局保健食品安全和技術(shù)規(guī)范專家委員會委員;國家科學技術(shù)獎勵評審專家;國家藥監(jiān)局保健食品、化妝品、獸藥評審專家;國家科技專家?guī)煸趲鞂<;教育部高校同行評議專家;江蘇省新藥及保健食品審評專家!端幬锓治鲭s志》、《中國藥科大學學報》編委。
人才計劃及主要榮譽江蘇省“333高層次人才培養(yǎng)工程”首批中青年科學技術(shù)帶頭人;青藍工程江蘇省中青年學術(shù)帶頭人;“十五”國家級重點教材《藥物分析》編委、省一類精品課程主要成員;《有機光譜分析》(副主編)獲國家醫(yī)藥管理局科技進步三等獎;江蘇省優(yōu)秀研究生課程《藥物光譜分析選論》負責人;2007、2009、2010年江蘇省優(yōu)秀研究生論文導師,2010年、2012年圣和研究生創(chuàng)新成果二等獎導師。
近年來科研工作:
1.國家自然科學基金項目負責人。
2.江蘇省科技廳科技支撐計劃項目負責人。
3.科技部重大新藥創(chuàng)制項目子課題負責人。
4.企業(yè)委托新藥質(zhì)量研究、體內(nèi)過程分析研究、代謝產(chǎn)物分析研究等項目負責人。
近年來代表性論文、論著:
1.An untargeted metabolomics-driven approach based on LC–TOF/MS and LC–MS/MS for the screening of xenobiotics and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma. Journal of Pharmaceutical and Biomedical Analysis. 2015,115: 315–322 .
2.An effective integrated method for comprehensive identification of eighty-five compounds in Zhi-Zi-Da-Huang decoction by HPLC-DAD-ESI-MS (TOF) and HPLC-DAD-ESI-MS/MS (QqQ) without the help of reference standards. Analytical method. 2014, 6:4312-4327.
3.Network Pharmacology-Based Antioxidant Effect Study of Zhi-Zi-Da-Huang Decoction for Alcoholic Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2015, 1- 6.
4.Optimization of the separation and determination of nitidine and chelerythrine in zanthoxylum nitidum by high-performance liquid chromatography with fluorescence detection. J Chromatogr Sci. 2014 , 52(2):164-168.
5.Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: restoration of monoamine neurotransmitters in discrete brain regions. Pharm Biol. 2013, 51(2):213-20.
6.A highly sensitive nonenzymatic glucose sensor based on CuO nanowires. Microchim Acta. 2012, 176:411-417.
7.Pharmacokinetics of Geniposide in Zhi-Zi-Hou-Pu Decoction and in Different Combinations of its Constituent Herbs. Phytotherapy Research. 2012, 26: 67-72
8.Pyrosequencing on nicked dsDNA generated by nicking endonucleases. Analytical Chemistry. 2010, 82(5):2074-81.
9.Determination of selected elements in aqueous extractions of a traditional Chinese medicine formula by ICP-MS and FAAS: evaluation of formula rationality. Analytical Letters, 2010, 43: 983-992.
10.Identification of components in Zhi-Zi-Da-Huang decoction by HPLC coupled with electrospray ionization tandem mass spectrometry, photodiode and fluorescence detectors. Journal of Pharmaceutical and Biomedical Analysis,.2009, 49, 1157-1165.
11.Evaluation of hepatoprotective effect of Zhi-Zi-Da-Huang decoction and its two fractions against acute alcohol-induced liver injury in rats. Journal of Ethnophamacology. 2009, 126, 273-279.
12.Influences of urinary pH on the pharmacokinetics of three amphetamine-type stimulants using a new high-performance liquid chromatographic method. Journal of Pharmaceutical Science. 2009, 98(2):728-38.
13.Development of a new pre-derivatization LC method for analysis of branched-chain and aromatic amino acids in rat plasma and to monitor their dynamic variation as a result of acute hepatic injury. Chromatographia, 2009, 70, 57-65.
14.主編《藥物分析》,東南大學出版社,2011年。
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