科研成果 |
發(fā)表文章60多篇,其中SCI文章40多篇;國際專利2項(xiàng),國內(nèi)專利1項(xiàng);參編專著2部。主要代表作如下( 帶*號為通信作者,帶+號為共同第一作者):
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Yachan Ji+, Jinquan Li+, Zhendong Qin, Aihua Li, Zemao Gu, Xiaoling Liu, Li Lin, Yang Zhou*. Contribution of nuclease to the pathogenesis of Aeromonas hydrophila.Virulence, 2015, accepted. SCI IF:3.319.
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Feifei Zheng, Muhammad Asim, Jiangfeng Lan, Lijuan Zhao, Shun Wei, Nan Chen, Xiaolin Liu, Yang Zhou*, Li Lin*.Danio rerio) during Infection with Aeromonas Sobria.Molecular Cloning and Functional Characterization of Mannose Receptor in Zebra Fish (International Journal of Molecular Sciences, 2015,16:10997-10112. SCI IF : 2.3
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Xianqin Hu, Xiaozhe Fu, Ningqiu Li*, Xingxing Dong,Lijuan Zhao,Jiangfeng Lan,WeiJi,Weidong Zhou, Taoshan Ai, Shuqin Wu, Li Lin*. Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways. Fish and Shellfish Immunology, 2015, 45:619-629. SCI IF:3.0. ( JCR 一區(qū))
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Dong X, Qin Z, Hu X, Lan J, Yuan G, Asim M, Zhou Y, Ai T, Mei J*, Lin L*. Molecular cloning and functional characterization of cyclophilin A in yellow catfish (Pelteobagrus fulvidraco). Fish and Shellfish Immunology, 2015,45:422-430. SCI IF:3.0.( JCR一區(qū))
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Li L, Luo Y, Gao Z, Huang J, Zheng X, Nie H, Zhang J, Lin L, Yuan J. Molecular characterisation and prevalence of a new genotype of Cyprinid herpesvirus 2 in mainland China. Can J Microbiol. 2015, 13:1-7. SCI IF:1.2.
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Wenjun Xu, Zhendong Qin, Hui Shi, Nan Jiang, Yang Zhou, Xiaoling Liu, Jianjun Xie,Genshen Wang, Weimin Wang, Muhammad Asim, Lingbing Zeng, Li Lin*. Mass mortality associated with a viral-induced anaemia in cage-reared large yellow croaker, Larimichthys crocea (Richardson). Journal of Fish Diseases, 2015;38(5):499-502. SCI IF: 1.5. ( JCR 二區(qū))
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Xiaodan Liu, Jiannan Huang, Shaoping Weng, Xianqin Hu, Wenjie Chen, Zhendong Qin, Xingxing Dong, Xiaoling Liu, Yang Zhou, Muhammad Asim, Weimin Wang, Jianguo He*, Li Lin*. Infections of nervous necrosis virus in wild and cage-reared marine fish from South China Sea with unexpected wide host ranges. Journal of Fish Diseases, 2015;38(6):533-40.SCI IF: 1.5. ( JCR 二區(qū))
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Wenwen Wang, Muhammad Asim, Lizhu Yi, Abeer M Hegazy, Xianqin Hu, Yang Zhou, Taoshan Ai, Li Lin*. Abortive infection of snakehead fish vesiculovirus in ZF4 cells was associated with the RLRs pathway activation by viral replicative intermediates . International Journal of Molecular Sciences, 2015;16(3):6235-50. SCI IF : 2.3
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Xiaodan Liu, Yi Wen, Xianqin Hu, Wenwen Wang, Xufang Liang, Jun Li, Vikram Vakharia, Li Lin* . Breaking the host range: Mandarin fish was susceptible to a vesiculovirus derived from snakehead fish. Journal of General Virology, 2015;96(Pt 4):775-81. SCI IF:3.5.
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Xiaoheng Zhao, Lichun Liu, Abeer M. Hegazy, Hong Wang, Jie Li, FeifeiZheng, Yang Zhou, Weimin Wang, Jun Li, Xiaoling Liu*, Li Lin*. Mannose receptor mediated phagocytosis of bacteria in macrophages of blunt snout bream (Megalobrama amblycephala) in a Ca2+-dependent manner. Fish and Shellfish Immunology, 2015; 43(2):357-363, SCI IF:3.0. ( JCR 一區(qū))
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Weidong Zhou, Yulei Zhang, Yi Wen, Wei Ji, Yang Zhou, Yachan Ji, Xiaoling Liu, Weimin Wang, Muhammad Asim, Xufang Liang*,Taoshan Ai*, Li Lin*. Analysis of the transcriptomic profilings ofMandarin fish (Siniperca chuatsi)infected with Flavobacterium columnare with an emphasis on immune responses. Fish Shellfish Immunol. 2015; 43(1): 111-119, SCI IF:3.0. ( JCR 一區(qū))
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Tran NT, Gao ZX, Zhao HH, Yi SK, Chen BX, Zhao YH, Lin L, Liu XQ, Wang WM*. Transcriptome analysis and microsatellite discovery in the blunt snout bream (Megalobrama amblycephala) after challenge with Aeromonas hydrophila. Fish and Shellfish Immunology, 2015, 45:72-82. SCI IF:3.0( JCR 一區(qū))
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Guangxin Liu, Li Lin, Min Wang, Xueqin Liu*. Development and evaluation of a loop-mediated isothermal amplification assay for the detection of channel catfish virus. Journal of Fish Diseases, 2015, Accepted. SCI IF: 1.7. (JCR二區(qū))
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Liu L, Zhu B, Wu S, Lin L, Liu G, Zhou Y, Wang W, Asim M, Yuan J, Li L, Wang M, Lu Y, Wang H, Cao J, Liu X*. Spring Viremia of Carp Virus Induces Autophagy for Necessary Viral Replication. Cell Microbiol. 2015, 17:595-605. SCI IF:4.8.
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Wu S, Liu L, Zohaib A, Lin L, Yuan J, Wang M, Liu X*. MicroRNA profile analysis of Epithelioma papulosum cyprini cell line before and after SVCV infection. Dev Comp Immunol. 2015, 48(1):124-8. SCI IF:3.7. ( JCR 二區(qū))
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Li Lin*, Weimin Wang*. Lung-Kidney Dual Functions of Fish Gill. Annals of Aquaculture and Research. 2014,1(1):1003.
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Yuan J, Yang Y, Nie H, Li L, Gu W, Lin L, Zou M, Liu X, Wang M, Gu Z*. Transcriptome analysis of epithelioma papulosum cyprini cells after SVCV infection. BMC Genomics. 2014, 15:935. SCI IF:4.0
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Liu L, Zhou Y, Zhao X, Wang H, Wang L, Yuan G, Asim M, Wang W, Zeng L, Liu X*, Lin L*. Oligochitosan stimulated phagocytic activity of macrophages from blunt snout bream (Megalobrama amblycephala) associated with respiratory burst coupled with nitric oxide production. Dev Comp Immunol. 47(1):17-24, 2014. SCI IF:3.7. ( JCR 二區(qū))
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Wang L, Liu L, Zhou Y, Zhao X, Xi M, Wei S, Fang R, Ji W, Chen N, Gu Z, Liu X, Wang W, Asim M, Liu X*, Lin L*, Molecular cloning and expression analysis of mannose receptor C type 1 in grass carp (Ctenopharyngodonidella), Dev Comp Immunol, 2014; 43(1):54-8.SCI IF:3.7.( JCR 二區(qū))
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Xiaoling Liu, Xiaocheng Tang, Li Wang, Jie Li, Hong Wang, Shun Wei, Rui Fang, Wei Ji, Gailing Yuan, Nan Chen, Zema Gu, Xueqin Liu, Weimin Wang, Muhammad Asim, Yang Zhou*, Li Lin*.Molecular cloning and expression analysis of mannose receptor in blunt snout bream (Megalobrama amblycephala). Molecular Biology Reports. 2014; 41(7):4601-11. SCI IF:2.5.
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Li Q, Liu L, Lin L, Li Z, Liu G, Wu S, Wang M, Li L, Yuan J, Yuan G, Liu X*. Immunization with recombinant baculovirus expressing the VP6 protein of grass carp reovirus induces immunity in grass carp. Virol Sin. 2014, 29(4):261-3
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Yang Y, Huang J, Li L, Lin L, Zhai Y, Chen X, Liu X, Wu Z, Yuan J*. Up-regulation of nuclear factor E2 - Related factor 2 upon SVCV infection. Fish Shellfish Immunol. 17;40(1):245-252, 2014. SCI IF:3.0( JCR 一區(qū))
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Luo YZ, Lin L, Liu Y, Wu ZX, Gu ZM1, Li LJ*,Yuan JF*. Haematopoietic Necrosis of Cultured Silver Prussian Carp (Carassius gibelio) Associated with Cyprinid Herpesvirus. Journal of Fish Diseases,36(12):1035-1039, 2013. SCI IF:2.0. ( JCR 二區(qū))
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Liyue Liu, Qin Li, Li Lin, Min Wang, Yuanan Lu, Weimin Wang, Junfa Yuan, Lijuan Li, Xueqin Liu*.Proteomic analysis of epithelioma papulosum cyprini cells infected with spring viraemia of carp virus. Fish and Shellfish Immunology, 35(1):26-35, 2013.SCI IF:3.0( JCR一區(qū))
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Hyun-Mi Pyo, Alex Masic, Nizihti Woldeab, Carissa Embury-Hyatt, Li Lin, Yeun-Kyung Shin, Jae-Young Song, Shawn Babiuk and Yan Zhou*. Pandemic H1N1 influenza virus like particles are immunogenic and provide protective immunity to pigs. Vaccine, 30: 1297-1304, 2012.SCI IF:3.5. (JCR二區(qū))
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Li Lin, Qiang Liu, Nathalie Berube, Yan Zhou*. 5’-triphosphate-siRNA: potent inhibition of influenza A virus infection by gene silencing and RIG-I activation. Journal of Virology, 86: 10359-10369, 2012.SCI IF:5.4. ( JCR 二區(qū))
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Li Lin, Yang Li, Hyun-Mi Pyo, Xinya Lu, Sathya Narayanan, Qiang Liu and Yan Zhou*.Identification of RNA helicase A as a cellular factor that interacts with influenza A NS1 protein and its role in virus life cycle. Journal of Virology, 86:1942-1954, 2012.SCI IF :5.4.( JCR 二區(qū))
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Rajeev Boregowda, Li Lin, Laurie Ludgate1, Qin Zhu, Fang Tian, and Jianming Hu*. Cryptic protein priming sites in two different domains of duck hepatitis B virus reverse transcriptase for initiating DNA synthesis in vitro. Journal of Virology, 85: 7754-7765,2011. SCI IF:5.4. ( JCR 二區(qū))
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Junhua Pan*, Li Lin*, Yizhi Jane Tao. Self-guanylylation of birnavirus VP1 does not require an intact polymerase activity site. Virology, 2009, 395(1):87-96. (* contributed equally). SCI IF:3.2. (JCR二區(qū))
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Pan J, Dong L, Lin L, Ochoa WF, Sinkovits RS, Havens WM, Nibert ML, Baker TS, Ghabrial SA, Tao YJ , Atomic structure reveals the unique capsid organization of a dsRNA virus. Proc Natl Acad Sci U S A. 2009,106(11):4225-30. SCI IF: 9.43. ( JCR 一區(qū))
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Jianming Hu and Li Lin. RNA-protein interactions in hepadnavirus reverse transcription. Front Biosci. 2009, 1; 14:1606-18. SCI IF: 3.7.
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Li Lin, F. Wan, and J Hu , Functional and Structural dynamics of Hepadnavirus Reverse Transcriptase During Protein-Primed Initiation of Reverse Transcription: Effects of Metal Ions. Journal of Virology, 2008, 82:5703-5714. SCI IF: 5.4. ( JCR 二區(qū))
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Li Lin and Hu, J. Inhibition of Hepadnavirus Reverse Transcriptase-ε RNA Interaction by Porphyrin Compounds. Journal of virology, 2008, 82: 2305-2312. SCI IF:5.4. ( JCR 二區(qū))
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Huang J. N.*, Lin L.*, S. P. Weng and J. G. He. High expression of capsid protein of red-spotted grouper nervous necrosis virus in an avian cell line requires viral RNA2 non-coding regions. Journal of Fish Diseases, 2007, 30: 439-444 (*contributed equally). SCI IF:1.7. ( JCR 二區(qū))
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Matthes E, A. Funk, I. Krahn, K. Gaertner, M. von Janta-Lipinski, L. Lin, H. Will, H. Sirma. Strong and Selective Inhibitors of HBV-Replication Between Novel N4-Hydroxy-and 5-Methyl-beta-L-deoxycytidine Analogues. Antimicrob Agents Chemother. 2007, 51:2523-2530. SCI IF:4.8. ( JCR 二區(qū))
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Li Lin , Alex Prassolov, Annke Funk, Hans Will, Hueseyin Sirma et al. Evidence from nature: interspecies spread of avian hepatitis B viruses. Journal of General Virology,2005 86:1335-42. SCI IF:3.4.
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Anneka Funk, Li Lin, Mouna Mhamdi, Hans Will, Hueseyin Sirma . Determinants of Hepadnaviral Species and Liver Cell Tropism. Monogr Virol. Basel, Karger, 2005, 25: 56-65.
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Sirma, H., A. Funk, H. Hohenberg, M. Petrimpol, M. Mhamdi, L. Lin, U. Schubert, H. Will. Functional modulation of virus-cell interactions by drugs: new concepts for treatment of viral hepatitis and hepatocellular carcinoma. In: Proc. 11th International Symposium on Viral Hepatitis and Liver Disease. Sydney, Australia (eds: A.R. Jilbert et al.), Australian Centre for Hepatitis Virology Publisher, ISBN 1877040266, 2004: 293-296.
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Anneke Funk, Mouna Mhamdi, Li Lin, Hans Will, Hueseyin Sirma. Itinerary of Hepatitis B Viruses:Delineation of Restriction Points. Journal of virology, 2004, 78:8289-8300. SCI IF:5.4. ( JCR 二區(qū))
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Li Lin , He J G, Mori K, et al. Mass mortalities associated with viral nervous necrosis in hatchery-reared groupers in the People’s Republic of China. Fish Pathology, 2001, 36: 186-188. SCI IF:1.07.
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陳文捷,劉曉丹, 胡先勤,王文文, 秦真東,王瑤,周洋, 劉小玲, 林蠡*. 魚類神經(jīng)壞死病毒研究進(jìn)展與發(fā)展趨勢. 水產(chǎn)學(xué)報,2014,38:1666-1670.
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劉曉丹,胡先勤,黃劍南,翁少萍,王文文,陳文捷,秦真東,董星星,周洋,劉小玲, 張學(xué)振,郭志勛,何建國*,林蠡*. 原位雜交和免疫熒光檢測魚類神經(jīng)壞死病毒在宿主魚組織中的分布.水生生物學(xué)報, 2014,38 (5): 876-882.
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黃劍南, 郭志勛, 馮娟, 林蠡*. 魚類諾達(dá)病毒及其所導(dǎo)致的疾病. 水產(chǎn)學(xué)報, 2006, 30(6): 831-836.
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林蠡,黃劍南, 翁少萍, 王云新,劉付永忠, 張海發(fā),何建國. 赤點(diǎn)石斑魚病毒性神經(jīng)壞死癥的組織病理和電鏡觀察. 水產(chǎn)學(xué)報, 2005, 29(4):519-523.
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Beta-L-nucleosides and their use as pharmaceutical agents and their use for therapy of viral diseases. US 2006/0217345 A1, World patent, WO2005/026186 A1.美國和德國專利
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Husbandry and Health Management of Grouper. Asia-Pacific Economic Cooperation Fisheries Working Group 01, 2000:1-94.(石斑魚的培育和健康養(yǎng)殖,亞太經(jīng)貿(mào)組織漁業(yè)工作組01,2000:1-94.)
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《中國海洋魚類單殖吸蟲》,張劍英等,中國農(nóng)業(yè)出版社,2001:1-400。
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