周長林簡介

1、簡歷

周長林，男，1964年1月生，1986、1989和1997年于華東理工大學生物工程專業(yè)分別獲學士、碩士和博士學位，1999.4-2000.3年日本近畿大學藥學部訪問學者，2004.12-2005.11年美國ProvidenceCollege生物系博士后�，F(xiàn)為中國藥科大學生命科學與技術學院副院長、教授、博士生導師，國家藥品食品監(jiān)督管理局化妝品評審專家、衛(wèi)生部第六屆獸藥評審專家，國家國際科技合作專項項目、中國博士后科學基金評審專家，擔任中國微生物學會酶工程專業(yè)委員會委員、江蘇省第九屆生物化學和分子生物學學會常務理事,《中國藥科大學學報》、《中國生化藥物雜志》、《藥物生物技術》、《藥學與臨床研究》雜志編委。2008年被評為江蘇省“青藍工程”中青年學術帶頭人。長期從事微生物與生化藥學教學和研究工作，主要研究方向為微生物代謝調控和藥物生物合成、抗感染藥物藥效學及其機理。主持多項國家、省部級和橫向科研課題。至今發(fā)表研究論文近100篇，其中SCI收錄30篇，申請多項發(fā)明專利（授權10項），主編出版教材4部。

2、研究方向

微生物代謝調控的分子機制和藥物生物合成、抗感染藥物藥效及機理。

3、近年來發(fā)表研究論文（SCI）

(1) Yang Yang, Chao Yuan, Jie Dou, Xiaorong Han, Hui Wang, Hongqing Fang, Changlin Zhou*. Recombinant expression of glpK and glpD genes improves the accumulation of shikimic acid in E. coli grown on glycerol. World J Microbiol Biotechnol (2014) 30: 3263-3272 (IF 1.779)
(2) Yue Ding, Jie Dou, Zaijin Teng, Jie Yu, Tingting Wang, Na Lu, Hui Wang, Changlin Zhou*. Antiviral activity of baicalin against influenza A (H1N1/ H3N2) virus in cell culture and in mice and its inhibition of neuraminidase. Arch Virol (2014), 159 (12): 3269-3278 (IF 2.39)
(3) Wang Y, Wang W, Lv Y, Zheng W, Mi Z, Pei G, An X, Xu X, Han C, Liu J, Zhou C*, Tong Y*. Characterization and complete genome sequence analysis of novel bacteriophage IME-EFm1 infecting Enterococcus faecium. J Gen Virol. 2014 Nov; 95(Pt 11): 2565-75 (IF 3.183)
(4) Mengyun Ke, Hui Wang, Min Zhang, Yuwei Tian, Yizhou Wang, Bing Li, Jie Yu, Jie Dou, Tao Xi, Changlin Zhou*. The anti-lung cancer activity of SEP is mediated by the activation and cytotoxicity of NK cells via TLR2/4 in vivo. Biochemical Pharmacology, 2014, 89: 119-130 (IF 5.009)
(5) Jing Wang, Bing Li, Yang Li, Jie Dou, Qingru Hao, Yuwei Tian, Hui Wang, Changlin Zhou*. BF-30 effectively inhibits ciprofloxacin-resistant bacteria in vitro and in a rat model of vaginosis. Arch Pharm Res. 2014, 37(7): 927-936 (IF 2.046)
(6) Yuwei Tian, Hui Wang, Bing Li, Mengyun Ke, Jing Wang, Jie Dou, Changlin Zhou*. The cathelicidin-BF Lys16 mutant Cbf-K16 selectively inhibits non-small cell lung cancer proliferation in vitro. Oncol Rep. 2013; 30: 2502-2510 (IF 2.297)
(7) Hui Wang, Mengyun Ke, Yuwei Tian, Jing Wang, Bing Li, Yizhou Wang, Jie Dou, Changlin Zhou*. BF-30 selectively inhibits melanoma cell proliferation via cytoplasmic membrane permeabilization and DNA-binding in vitro and in B16F10-bearing mice. European Journal of Pharmacology. 2013; 707: 1-10 (IF 2.592)
(8) Qingru Hao, Hui Wang, Jing Wang, Jie Dou, Min Zhang, Weidong Zhoua, Changlin Zhou*. Effective antimicrobial activity of Cbf-K16 and Cbf-A7A13 against NDM-1-carrying Escherichia coli by DNA binding after penetrating the cytoplasmic membrane in vitro. J. Pept. Sci. 2013; 19: 173–180 (IF 2.071)
(9) Kai Chen, Jie Dou, Shirui Tang, Yishun Yang, Hui Wang, Hongqing Fang, Changlin Zhou*. Deletion of the aroK gene is essential for high shikimic acid accumulation through the shikimate pathway in E. coli. Bioresource Technology, 2012 May 29; 119C: 141-147 (IF 4.75)
(10) Zhenzhen Su, Jie Dou, Zhipeng Xu, Qinglong Guo, Changlin Zhou*. A novel inhibitory mechanism of baicalein on influenza A/FM1/1/47 (H1N1) virus: interference with mid-late mRNAs synthesis in cell culture. Chinese Journal of Natural Medicines. 2012, 10(6): 415-420 (SCIE)
 (11) Xitao Cao, Minghua Yang, Jie Dou, Kai Chen, Hui Wang, Tao Xi, Changlin Zhou*. Strain improvement for enhanced production of S-adenosyl-L-methionine in Saccharomyces cerevisiae based on ethionine-resistance and SAM synthetase activity. Ann Microbiol. (2012) 62:1395–1402 (IF 1.549)
(12) Mengyu Wang, Hui Wang, Ying Tang, Di Kang, Yu Gao, Mengyun Ke, Jie Dou, Tao Xi , Changlin. Zhou*. Effective inhibition of a Strongylocentrotus nudus eggs polysaccharide against hepatocellular carcinoma is mediated via immunoregulation in vivo. Immunol Lett. 2011 Dec 30; 141(1): 74-82 (IF 2.526)
(13) Hui Wang , Mengyu Wang , Jing Chen , Ying Tang, Jie Dou, Jian Yu, Tao Xi, Changlin Zhou* . A Polysaccharides from Strongylocentrotus nudus eggs (SEP) activated splenocytes proliferation in immunosuppressed mice via PI-3k/Akt signaling pathway. International Immunopharmacology, 2011, 11 (11): 1946-1953 (IF 2.376)
(14) Lili Chen, Jie Dou, Zhenzhen Su, Huimin Zhou, Hui Wang, Weidong Zhou, Qinglong Guo, Changlin Zhou*. Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Research. 2011, 91(3): 314-320 (IF 4.301)
(15) Huimin Zhou, Jie Dou, Jing Wang, Lili Chen, Hui Wang, Weidong Zhou, Yunman Li, Changlin Zhou*. The antibacterial activity of BF-30 in vitro and in infected burned rats is through interference with cytoplasmic membrane integrity. Peptides. (2011), 32(6): 1131-1138 (IF 2.434)
(16) Ren Y, Fang H, Dai H, Li S, Chen H, Zhou C, Yao X. Production of Nalpha-acetylated thymosin alpha1 in Escherichia coli. Microb Cell Fact. 2011 Apr 22; 10 (1):26 (IF 3.552)
(17) Jie Dou, Lili Chen, Ge Xu, Lei Zhang, Huimin Zhou, Hui Wang, Zhenzhen Su, Mengyun Ke, Qinglong Guo, Changlin Zhou*. Effects of Baicalein on Sendai Virus In Vivo Are Linked to Serum Baicalin and Its Inhibition of Hemagglutinin-Neuraminidase. Arch Virol (2011), 156(5):793–801（IF 2.111）

4、聯(lián)系方式

中國藥科大學，生命科學與技術學院，微生物學教研室；

江蘇省南京市中央路童家巷24號，郵編：210009；

Tel.:025-8327-1323，F(xiàn)ax:025-8327-1249；

E-mail:cl_zhou@cpu.edu.cn