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分類:導(dǎo)師信息 來(lái)源:中國(guó)考研網(wǎng) 2016-07-19 相關(guān)院校:中國(guó)藥科大學(xué)
李泰明,女,博士,副教授,生物制藥教研室主任,藥大工作24年,日本進(jìn)修1年。承擔(dān)多項(xiàng)國(guó)家課題,獲得國(guó)家、省級(jí)獎(jiǎng)勵(lì)多項(xiàng)。發(fā)表文章:60多篇,專利10多項(xiàng),出版教材多本。
①本人研究方向:
1.對(duì)糖尿病及其并發(fā)癥有治療作用的功能肽研究及新型肽疫苗設(shè)計(jì)。
2.基因工程技術(shù)構(gòu)建融合蛋白藥物及其發(fā)酵分離純化質(zhì)量控制研究。
②研究成果
代表文章
1.Taiming Li1*(通訊作者). Enhanced antitumor efficacy by combination treatment with a human umbilical vein endothelial cell vaccine and a tumor cell lysate-based vaccine。Tumour Biol. 2013 Oct;34(5):3173-82. SCI
2.Taiming Li*(通訊作者)Improved efficacy of therapeutic vaccination with viable human umbilical vein endothelial cells against murine melanoma by introduction of OK432 as adjuvant.Tumour Biol. 2013 Jun;34(3):1399-408. SCI
3. Taiming L. *(通訊作者)Generation of a Chimeric Plasmin-Resistant Vegf165/Vegf183 (132-158) Protein and its Comparative Activity. Protein Pept Lett. 2013 Aug;20(8):947-54.
4.Taiming Li1*(通訊作者).Immunization with P277 induces vascular leak syndrome in C57BL/6 mice via endothelial damage。Autoimmunity 2010, 43(8)8:654-663 SCI
5.Taiming Li1*(通訊作者).Specific Antibodies Elicited by a Novel DNA Vaccine Targeting Gastrin-Releasing Peptide Inhibit Murine Melanoma Growth In Vivo. American Society for Microbiology. 。Clinical and Vaccine Immunology, 2009,16(7): 1033–1039 SCI
6.Taiming Li1*(通訊作者).Nasal immunization with heat shock protein 65 attenuates atherosclerosis and reduces serum lipids in cholesterol-fed wild-type rabbits probably through different mechanisms. Immunology Letters 2009, 125:40–45 SCI
7.Taiming Li1*(通訊作者).Construction, Expression, Purification and Immunology Effect of an Anti-Atherosclerosis Chimeric Enzyme Vaccine in Escherichia coli。Immunology Letters 2009, 125:40–4。P rotein & Peptide Letters,2008, 15:7 SCI
8.Taiming Li*(通訊作者).Study on preparation and unique properties of a novel insulin analogue with N-terminal Arg-4, Pro-3, Lys-2, Pro-1extension at insulin B-chain。Regulatory Peptides. 2009,157(1-3). SCI
9.Taiming Li*(通訊作者)Quantification of recombinant human relaxin-2 (B-29/A-24) in non-pregnant rat plasma using ultra performance liquid chromatography-mass spectrometry Anal. Methods, 2014,SCI
10.李泰明(第一作者)Cloning, expressing of exendin-4 analogue and bioactivity analysis in vivo. Sheng Wu Gong Cheng Xue Bao. 2012 Jul;28(7):877-86
12. 李泰明(通訊作者)Protective antitumor immunity induced by tumor cell lysates conjugated with。diphtheria toxin and adjuvant epitope in mouse breast tumor model. Chinese Journal of Cancer,2012; 31(6),295-305
出版教材
《生物制藥技術(shù)》2003化學(xué)工業(yè)出版社。第一版,人民衛(wèi)生出版社(國(guó)家“十一五”規(guī)劃教材)
《生物工程》2009中國(guó)醫(yī)藥科技出版社。第一版,(規(guī)劃教材)
《分子生物學(xué)實(shí)驗(yàn)與指導(dǎo)》2003中國(guó)醫(yī)藥科技出版社第一版,(規(guī)劃教材)
《生物制藥工藝學(xué)實(shí)驗(yàn)與指導(dǎo)》2008中國(guó)醫(yī)藥科技出版社。第一版,(規(guī)劃教材)
專利10多項(xiàng)
1.李泰明(第一)。一種Exendin-4類似物。2013授權(quán)
2.李泰明(第一);一種具有降血糖作用的新型肽。201310193522.3公開(kāi)
3.李泰明(第一)。一種Exendin-4類似物及其制備方法和應(yīng)用.2013公開(kāi)
4.李泰明(第一)一種人胰高血糖素樣肽-2(1-35肽)類似物制備方法。2011公開(kāi)CN102190720A
5.李泰明(第一)人胰高血糖素相關(guān)肽-1類似物2012公開(kāi)CN102796192A.
6.李泰明(第一)一種新型血管內(nèi)皮細(xì)胞疫苗及其制備方法。2012公開(kāi)CN102793914A.
7.李泰明(第二)人胰高血糖素相關(guān)肽-2類似物。授權(quán)專利號(hào)ZL200510039265.2008授權(quán)
③聯(lián)系方式
Address:School of Biopharmaceutics,
China Pharmaceutical University
24# TongJiaXiang Nanjing
210009P,R.China
Tel:13337717730
E-mail:taimingli@163.com
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