高緣簡介

教育經(jīng)歷：

1990.9-1994.7中國藥科大學藥劑學專業(yè)學士

1996.9-2000.10中國藥科大學藥劑學專業(yè)碩士

2001.12-2005.4香港中文大學藥學專業(yè)博士

工作經(jīng)歷：

1994.8-2004.10中國藥科大學講師，年級主任

2006.4-2006.10國家食品藥品監(jiān)督管理局藥品審評中心（SFDA）

2009.9-2010.10無錫江陰市高新技術(shù)創(chuàng)業(yè)園管委會副主任（省科技人才掛職）

2010.7-2011.12江蘇四環(huán)生物股份有限公司總經(jīng)理助理（企業(yè)柔性人才掛職）

2005-2013.7中國藥科大學天然藥物實驗中心副教授，副主任

2013.8-至今中國藥科大學天然藥物實驗中心教授，博士生導師,副主任

基本情況：

具有全面、規(guī)范的中藥新藥審評培訓經(jīng)歷，系統(tǒng)、現(xiàn)代的中藥研究經(jīng)歷和豐富的中、西藥生產(chǎn)研發(fā)經(jīng)驗。將共晶、液晶、納晶等新技術(shù)引入到藥物研發(fā)領(lǐng)域，取得突破性成果；在口腔粘膜給藥系統(tǒng)、緩控釋給藥系統(tǒng)、微粒給藥系統(tǒng)等形成特色的研究方向；在抗腫瘤、心腦血管、抗感染、中樞神經(jīng)系統(tǒng)等領(lǐng)域研發(fā)方向明確。

應(yīng)用產(chǎn)業(yè)化成熟度高。申請專利12項，獲得授權(quán)專利6項；與國內(nèi)外企業(yè)簽訂新制劑與新給藥系統(tǒng)合作開發(fā)協(xié)議近20項，目前已有13項均已通過了企業(yè)生產(chǎn)線工藝驗證，產(chǎn)業(yè)化成果顯著。

注重制劑的基礎(chǔ)理論研究，為211引進人才；2010年獲得江蘇省“六大人才高峰”計劃（A類）；目前獲得國家、省部級等各類基金10余項；發(fā)表SCI論文20余篇；擔任國際期刊AAPS Pharma Sci Tech，International Journal of Pharmaceutics審稿專家。

主要研究方向：

1）藥物制劑新劑型與新技術(shù)研究

2）微粒給藥系統(tǒng)的研究

3）中藥與輔料相互關(guān)系的研究

4）天然藥物的研發(fā)與評價

代表性論文：

Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion. Int J Pharm, 2011, 414(1-2):186-192.

Preparation and evaluation of glyceryl monooleate-coated hollow-bioadhesive microspheres for gastroretentive drug delivery. Int J Pharm, 2011, 413(1-2):103-109.

Physicochemical and pharmacokinetic characterization of a spray-dried cefpodoxime proxetil nanosuspension. Chem Pharm Bull 2010, 58(7): 912-917.

Interaction characteristics with bovine serum albumin and retarded nitric oxide release of ZCVI(4)-2, a new nitric oxide-releasing derivative of oleanolic acid. Chem Pharm Bull. 2011, 59(6): 734-741.

Enhanced dissolution and stability of adefovir dipivoxil by cocrystal formation. J Pharm Pharmacol, 2011, 63(4): 483–490.

Formation thermodynamics of adefovir dipivoxil-saccharin co-crystals. Acta Phys Chim Sin, 2011, 27(3): 547-552. 

Pharmaceutical cocrystals. Prog Chem, 2010,22(5): 829-836.

Optimization of preparation and property studies on glycosylated albumin as drug carrier for nanoparticles. Pharmazie, 2011, 66(7): 484-490.

Albumin as drug carriers. Prog Chem, 2011, 23(8): 168-176.

10. Effect of poloxamer F 127 and paeonol on GMO-based liquid crystal transformation. Acta Chim Sin, 2011, 69(13): 1503-1508.

Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm. 2011, 420(1):180-188.

Spray-dried oil-in-water emulsion to improve the intestinal absorption and oral bioavailability of ZLR-8, a nitric oxide-releasing derivative of diclofenac. J Pharm Pharmacol, 2011, 63(12):1531-1538.

Physicochemical characterization and an injection formulation study of water insoluble ZCVI4-2，a novel NO-donor anti-cancer compound. Arch Pharm Res, 2012, 35(7): 1177-1186.

Biopharmaceutics classification and intestinal absorption study of apigenin. Int J Pharm, 2012, 436(1-2): 311-317.

Coformer selection based on degradation pathway of drugs: a case study of adefovir dipivoxil-saccharin and adefovir dipivoxil-nicotinamide cocrystals. Int J Pharm, 2012, 438(1-2): 327-335

Comparative pharmacokinetic study of chlorogenic acid after oral administration of lonicerae japonicae flos and shuang-huang-lian in normal and febrile rats. Phytother Res, 2014, 28(1):144-147.

Simultaneous determination of four alkaloids in mice plasma and brain by LC-MS/MS for pharmacokinetic studies after administration of Corydalis Rhizoma and Yuanhu Zhitong extracts. J Pharm Biomed Anal, 2014, 92:6-12.

專著：

1）高緣（主編）.國家執(zhí)業(yè)藥師資格考試中藥學專業(yè)知識（一）.中國協(xié)和醫(yī)科大學出版社

2）高緣（副主編）.現(xiàn)代中藥制劑新技術(shù).江蘇科學技術(shù)出版社

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