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分類:導(dǎo)師信息 來源:中國考研網(wǎng) 2016-07-14 相關(guān)院校:中國藥科大學(xué)
殷志琦,女,博士,副教授,碩士研究生導(dǎo)師,天然藥物化學(xué)教研室副主任。
學(xué)習(xí)、工作經(jīng)歷
2014.4-至今中國藥科大學(xué)天然藥化教研室教研室副主任
2013.4-2014.4美國伊利諾伊大學(xué)芝加哥校區(qū)藥學(xué)院(訪問學(xué)者/副教授)
2003.3-2004.3香港科技大學(xué)生物系(訪問學(xué)者)
2002.7-2013.4中國藥科大學(xué)天然藥化教研室副教授
2001.2-2002.2香港科技大學(xué)生物系(訪問學(xué)者)
1997.9-2002.6中國藥科大學(xué)藥物化學(xué)專業(yè)博士學(xué)位
榮譽(yù)和兼職
江蘇省高校“青藍(lán)工程”優(yōu)秀青年骨干教師培養(yǎng)對(duì)象
江蘇省第九批“六大人才高峰”高層次人才
第三屆江蘇省中醫(yī)藥十佳青年之星
藥學(xué)會(huì)成員
Chinese Chemical Letters青年編委
國家自然科學(xué)基金醫(yī)學(xué)部同行評(píng)議專家
南京市、山東省、吉林省科技評(píng)審專家
Food Hydrocolloids、Food and Function、Phytomedicine、Natural Product Research、Molecules、Fitoterapia、Chinese Chemical Letters、中國天然藥物等雜志審稿人
研究方向
1.招生方向
1007Z9★天然藥物化學(xué):天然藥物與中藥的活性成分研究
1008Z1★中藥化學(xué):中藥化學(xué)成分研究及新藥開發(fā)
2.研究方向
(1)新穎骨架/結(jié)構(gòu)天然化合物的發(fā)現(xiàn)與活性研究
(2)治療代謝綜合癥(如高血脂、糖尿病、肥胖、非酒精性脂肪肝等)的中藥和天然藥物的研究與開發(fā)
(3)天然小分子靶向藥物的發(fā)現(xiàn)、構(gòu)效關(guān)系和作用機(jī)制的研究及應(yīng)用,包括腫瘤靶向藥物和診斷試劑,心肌活性診斷試劑,影像對(duì)比劑的研究、構(gòu)建與開發(fā)。
研究成果
1.教學(xué)成果
承擔(dān)本科生《天然藥物化學(xué)》、《波譜解析》、《專業(yè)英語》,研究生《中藥、天然藥物研究基礎(chǔ)、方法與思路》等課程。
作為主講教師之一的《天然藥物化學(xué)》獲國家級(jí)、省級(jí)、校級(jí)精品課程;榮獲江蘇省高等學(xué)校優(yōu)秀多媒體教學(xué)課件一等獎(jiǎng)1項(xiàng),省級(jí)微課比賽二等獎(jiǎng)1項(xiàng)、校級(jí)教學(xué)成果一等獎(jiǎng)1項(xiàng),校級(jí)優(yōu)秀多媒體教學(xué)課件競賽獲二等獎(jiǎng)等。
參與編寫教材《天然藥物化學(xué)實(shí)驗(yàn)與指導(dǎo)》(雙語)以及《中藥制藥化學(xué)》,均已出版。
2.科研成果
課題資助
a)國家自然科學(xué)基金:基于TrkB靶標(biāo)研究杠柳和青陽參中去氧糖類成分抗癲癇活性的作用機(jī)制和構(gòu)效關(guān)系(2011.1-2013.12,編號(hào)81001379,主持)b)中央高;究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金扶貧項(xiàng)目:鎮(zhèn)坪道地藥材黃連降血脂藥效物質(zhì)基礎(chǔ)比較研究(2014.1-2014.12,主持)c)江蘇省第九批“六大人才高峰”高層次人才項(xiàng)目(2013.1-2015.12,編號(hào)2012-YY-008,主持)d)江蘇省高校“青藍(lán)工程”優(yōu)秀青年骨干教師(2010.12-2012.12,主持)e)中國藥科大學(xué)中央高;究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金重點(diǎn)項(xiàng)目:基于TrkB靶標(biāo)研究去氧糖類成分抗癲癇活性的作用機(jī)制和構(gòu)效關(guān)系(2010.7-2013.6,主持)f)“重大新藥創(chuàng)制”科技重大專項(xiàng)“十一五”計(jì)劃:豬牙皂總皂苷治療類風(fēng)濕關(guān)節(jié)炎候選藥物研究(2009.1-2010.12,編號(hào)2009ZX09103-392,第二,藥學(xué)部分負(fù)責(zé)人,完成)g)江蘇省高校自然科學(xué)研究計(jì)劃項(xiàng)目:蘇北沿海灘涂植物中華補(bǔ)血草抗腫瘤作用的發(fā)現(xiàn)與研究(2008.07-2010.12,編號(hào)08KJB360011,參加,完成)
h)國家自然科學(xué)基金:桑樹中氮糖化合物與其內(nèi)生菌相關(guān)性研究(2005.1-2007.12,編號(hào)30472146,參加,完成)
i)教育部科學(xué)技術(shù)研究項(xiàng)目:桑樹中具降糖活性的氮糖類化合物與其內(nèi)生菌相關(guān)性研究(2003年7月-2005年7月,編號(hào)104098,參加,完成)
研究生培養(yǎng)
協(xié)助指導(dǎo)博士2人(已畢業(yè))和碩士研究生15人,獨(dú)立指導(dǎo)碩士研究生34人
1名科學(xué)碩士和1名專業(yè)碩士的畢業(yè)論文榮獲2015年江蘇省優(yōu)秀碩士論文
近期代表性論文(已發(fā)表研究論文近100篇)
[1]XuejiaoLiu, Cuihua Jiang, Dongjian Zhang, Meng Gao, Fei Peng, Dejian Huang, Ziping Sun, Yicheng Ni, Jian Zhang*, Zhiqi Yin*. Tumor Necrosis Targeted Radiotherapy of Non-Small Cell Lung Cancer Using Radioiodinated Protohypericin in a Mouse Model. Oncotarget, 2015, accepted (IF 6.359)
[2]Kuiniu Zhu, Cuihua Jiang, Y.S. Tian, N. Xiao, Zhengfeng Wu, Yonglan Ma, Zi Lin, Sshengzuo Fang, Xulan Shang, Kang Liu, Jian Zhang, Baolin Liu*, Zhiqi Yin*. Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: the relationship to AMPK activation. Phytomedicine, 2015, DOI:10.1016/j.phymed.2015.05.058 (IF 3.126)
[3]Xuejiao Liu, Yuanbo Feng, Cuihua Jiang, Bin Lou, Yue Li, Wei Liu, Nan Yao, Meng Gao, Yun Ji, Qingqing Wang, Dejian Huang, Zhiqi Yin*, Ziping Sun, Yicheng Ni, Jian Zhang*. Radiopharmaceutical evaluation of 131I-protohypericin as a necrosis avid compound. Journal of Drug Targeting, 2015, 23(5): 417-426. (IF 2.741)
[4]Yonglan Ma, Cuihua Jiang, Nan Yao, Yue Li, Qingqing Wang, Shengzuo Fang, Xulan Shang, Ming Zhao, Chuntao Che, Yicheng Ni, Jian Zhang, Zhiqi Yin*. Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice. Journal of Ethnopharmacology, 2015, 166: 286-296 (IF 2.998)
[5]Dongjian Zhang(#), Dejian Huang, Yun Ji(#), Cuihua Jiang, Yue Li, Meng Gao, Nan Yao, Xuejiao Liu, Haibo Shao, Su Jing, Yicheng Ni, Zhiqi Yin*, Jian Zhang*. Experimental evaluation of radioiodinated sennoside B as a necrosis-avid tracer agent. J Drug Target, 2015, 23(2): 180-190 (IF 2.741)
[6]Xuejiao Liu, Cuihua Jiang,Yue Li, Wei Liu, Nan Yao, Meng Gao,Yun Ji, Dejian Huang, Zhiqi Yin, Ziping Sun, Yicheng Ni, Jian Zhang*. Evaluation of Hypericin: Effect of Aggregation on Targeting Biodistribution. Journal of Pharmaceutical Sciences, 2015, 104(1): 215-222 (IF 2.59)
[7]Yun Ji, Cuihua Jiang, Xueli Zhang, Wei Liu, Meng Gao, Yue Li, Junhu Wang, Qingqing Wang, Ziping Sun, Xiao Jiang, Nan Yao, Xiaoning Wang, Zhijun Fang, Zhiqi Yin*, Yicheng Ni, Jian Zhang. Necrosis-targeted combinational theragnostic approach to treat cancer. Oncotarget, 2014, 5(10): 2934-2946 (IF 6.359)
[8]Ming Zhao, Xianming Zhang, Yan Wang, Min Huang, Jin-Ao Duan, Tanja Gödecke, Karina M. Szymulanska-Ramamurthy, Zhiqi Yin, Chun-Tao Che. Germacranes and m-Menthane from Illicium lanceolatum. Molecules, 2014,19, 4326-4337 (IF 2.428)
[9]Cuihua Jiang, Nan Yao, Qingqing Wang, Jinghua Zhang, Yan Sun, Na Xiao, Kang Liu, Fang Huang, Shengzuo Fang, Xulan Shang, Baolin Liu, Yicheng Ni, Zhi-Qi Yin*, Jian Zhang. Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice. Journal of Ethnopharmacology, 2014, 153(2): 344-351 (IF 2.755)
[10]Yun Ji,Ying Zhan, Cuihua Jiang, Xiao Jiang,Meng Gao, Wei Liu, Yue Li, Junhu Wang, Qingqing Wang, Marlein Miranda Cona, Nan Yao, Xiaoning Wang, Zhijun Fang, Zhiqi Yi*, Jian Zhang, Ziping Sun and Yicheng Ni. Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis. J Drug Target, 2014, 22(4):304-312 (IF 2.768)
[11]Jun-Min Shi, Liang-Liang Bai, Dong-Mei Zhang*, Anita Yiu, Zhi-Qi Yin, Wei-Li Han, Jun-Shan Liu, Yong Li, Deng-Yue Fu, Wen-Cai Ye*. Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress, Biochemical Pharmacology, 2013, 85(7): 913-926 (IF 4.576)
[12]Xiao-Jun Huang, Lei Wang, Meng Shao, Shu-Zhi Hu, Ren-Wang Jiang, Xin-Sheng Yao, Yao-Lan Li, Zhi-Qi Yin*, Ying Wang* and Wen-Cai Ye*. Oleonin, the first secoiridoid with 1 alpha-configuration from Ligustrum lucidum , RSC Advances, 2013, 3(37), 16300-16303. (IF 2.562)
[13]Qingqing Wang, Cuihua Jiang, Shengzuo Fang, Junhu Wang, Yun Ji, Xulan Shang, Yicheng Ni, Zhiqi Yin*, Jian Zhang. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. Journal of Ethnopharmacology, 2013, 150: 1119-1127 (IF 2.755)
[14]Jun Chu, Songlin Li, Zhiqi Yin*, Wencai Ye, Qingwen Zhang*. Simultaneous quantification of coumarins, flavonoids and limonoids in Fructus Citri Sarcodactylis by high performance liquid chromatography coupled with diode detector. Journal of Pharmaceutical and Biomedical Analysis, 2012, 66: 170-175. (IF 2.967)
[15]Lei Wang, Zhiqi Yin*, Qingwen Zhang, Xiaoqi Zhang, Dongmei Zhang, Kang Liu, Yaolan Li, Xinsheng Yao and Wencai Ye. Five New C21 Steroidal Glycosides from Periploca sepium. Steroids, 2011, 76:238-243 (IF 3.106)
[16]Lei Wang, Zhqi Yin*, Ying Wang, Xiaoqi Zhang, Yaonan Li, Wencai Ye. Perisesaccharides A-E, New Oligosaccharides from the Root Barks of Periploca sepium. Planta Medica, 2010,76: 909-915 ( IF 2.037)
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E-mail:chyzq2005@126.comorcpu-yzq@cpu.edu.cn
通訊地址:
江蘇省南京市鼓樓區(qū)童家巷24號(hào)中國藥科大學(xué)天然藥化教研室(210009)
江蘇省南京市江寧區(qū)龍眠大道639號(hào)中國藥科大學(xué)天然藥化教研室(211198)
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