網(wǎng)站介紹 關(guān)于我們 聯(lián)系方式 廣告業(yè)務 幫助信息
1998-2022 ChinaKaoyan.com Network Studio. All Rights Reserved. 滬ICP備12018245號
分類:導師信息 來源:中國考研網(wǎng) 2016-07-13 相關(guān)院校:中國藥科大學
陳君,女,博士,副教授,博士研究生導師。2000年7畢業(yè)于中國藥科大學中藥制藥專業(yè),獲學士學位;2006年7月畢業(yè)于中國藥科大學生藥學專業(yè),獲博士學位,并留校任教,F(xiàn)為生藥學藥用植物學教研室主任。
主要從事中藥活性成分發(fā)現(xiàn)與質(zhì)量評價研究,主要通過建立基于親和色譜、液相色譜-質(zhì)譜聯(lián)用技術(shù)、生物技術(shù)的新方法、新技術(shù),發(fā)現(xiàn)與評價中藥復雜體系中活性成分(群),進而闡明中藥藥效物質(zhì)、開展中藥質(zhì)量標準及新藥開發(fā)研究。
主持國家自然科學基金項目3項(面上項目:基于丹參酮小分子探針研究其抗血管內(nèi)皮細胞氧化應激損傷的分子靶標及調(diào)控機制81573705;面上項目:多靶垂釣/成分在線捕獲方法的建立及在抗老年癡呆中藥藥效物質(zhì)群研究中的應用81073006;青年科學基金項目:高效液相偶聯(lián)自由基捕獲檢測系統(tǒng)用于中藥抗氧化效應評價及其物質(zhì)基礎(chǔ)研究30801521),入選教育部“新世紀優(yōu)秀人才支持計劃”;完成了2010年版《中國藥典》山銀花、萹蓄等品種的質(zhì)量標準起草;作為研究骨干參與國家自然科學基金創(chuàng)新群體項目、重點項目和國家重大科技專項“重大新藥創(chuàng)制”等課題的研究工作,為教育部創(chuàng)新團隊、江蘇省創(chuàng)新團隊的主要成員。近五年來,在Journal of Chromatography A、Analytical Bioanalytical Chemistry、Journal of Functional Foods等國際雜志發(fā)表SCI收錄論文34篇,獲授權(quán)發(fā)明專利7項。獲2013年度教育部自然科學一等獎(排名第四),2009年度國家科學技術(shù)進步二等獎(排名第九),2007年度教育部自然科學一等獎(排名第九)。指導本科生完成的作品獲第十二屆“挑戰(zhàn)杯”全國大學生課外學術(shù)科技作品競賽江蘇省三等獎,指導本科生開展的國家大學生創(chuàng)新性實驗計劃項目入圍第四屆全國大學生創(chuàng)新年會學術(shù)論文大賽(2011年)。
研究成果
1、10篇代表性論文(*為通訊作者):
1)Jing Liu, Li-Ping Luo, Hui Zhang, Bing-Jie Jia, Jin-Jin Lu, Ping Li, Jun Chen*. Rapid screening for nover antioxidants in Glycyrrhiza inflata using high-resolution peak fractionation. Journal of Functional Foods, 2015, 16:40-49.
2)Hui Zhang, Li-Ping Luo, Hui-Peng Song, Hai-Ping Hao, Ping Zhou, Lian-Wen Qi, Ping Li*, Jun Chen*. A high-resolution peak fractionation approach for streamlined screening of NF-E2-related factor-2 activators in Salvia miltiorrhiza. Journal of Chromatography A, 2014, 1326:47-55.
3)Yu Fu, Huan-Yan Mo, Wen Gao, Jia-Ying Hong, Jun Lu, Ping Li*, Jun Chen*. Affinity selection-based two-dimensional chromatography coupled with high-performance liquid chromatography-mass spectrometry for discovering xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae. Analytical Bioanalytical Chemistry, 2014, 406(20):4987-95.
4)Jun Lu, Hui-Peng Song, Ping Li*, Ping Zhou, Xin Dong, Jun Chen*. Screening of direct thrombin inhibitors from Radix Salviae Miltiorrhizae by a peak fractionation approach. Journal of Pharmaceutical and Biomedical Analysis, 2015, 109:85-90.
5)Hui-Peng Song, Hui Zhang, Yu Fu, Hua-Yan Mo, Mu Zhang, Jun Chen*, Li Ping*. Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC-MS combined with enzyme channel blocking. Journal of Chromatography B, 2014, 961:56-61.
6)Yu Fu, Jun Chen*, Yan-Jing Li, Yun-Feng Zheng, Ping Li*. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. Food Chemistry, 2013, 141:1064-1071.
7)Wen Gao, Hua Yang, Lian-Wen Qi, E-Hu Liu, Mei-Ting Ren, Yu-Ting Yan, Jun Chen*, Ping Li*. Unbiased metabolite profiling by liquid chromatography- quadrupole time-of-flight mass spectrometry and multivariate data analysis for herbal authentication: classification of seven Lonicera species flower buds. Journal of Chromatography A, 2012, 1245:109-116.
8)Yan-Jing Li, Jun Chen*, Ying Li, Qin Li, Yun-Feng Zheng, Yu Fu, Ping Li*. Screening and charactrerization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Journal of Chromatography A, 2011, 1218:8181-8191.
9)Mei-Ting Ren, Jun Chen*, Song Yue, Long-Sheng Sheng, Li Ping*, Lian-Wen Qi. Identification and quantification of thirty-two bioactive compounds in Lonicera species by high performance liquid chromatography coupled with time-of-flight mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis. 2008, 48:1351-1360.
10)Yan-Jing Li, Huan-Li Wei, Lian-Wen Qi, Jun Chen*, Mei-Ting Ren, Ping Li*. Characterization and identification of saponins in Achyranthes bidentata by rapid-resolution liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2010, 24:2975-2985.
2、專利:
1)丹酚酸C在制備防治高尿酸血癥藥物中的應用.陳君,李萍,高雯.ZL201210000772.6.已授權(quán).
2)一種黃酮化合物預防或治療炎癥性疾病的用途.陳君,李萍,李艷靜,付鈺.ZL201110398561.8.已授權(quán).
3)一種黃酮化合物在制備預防或治療腫瘤藥物中的用途..陳君,李萍,王一方,劉靜,付鈺,鄭云楓.ZL201310112169.1.已授權(quán).
4)一種常春藤皂苷、其制備方法及其抗腫瘤用途.李萍,陳君,湯丹.ZL200710135566.5.已授權(quán).
5)一種適用于天然產(chǎn)物高通量篩選的化合物庫高效制備方法.李萍,陳君,張慧,羅麗平,宋慧鵬,周萍.2013100326266,已申請.
6)丹參新酮在制備保護血管內(nèi)皮細胞的藥物中的用途.陳君,李萍,羅麗平,張慧,宋慧鵬,周萍,劉鄂湖.201310128667.5,已申請.
7)青蒿素及青蒿琥酯抗阿爾茨海默病的醫(yī)療用途.李萍,陳君,徐曉軍,王菊,石子琪.201210380878.3,已申請.
聯(lián)系方式
E-mail:chenj2002cpu@126.com
電話:025-83271382
掃碼關(guān)注
考研信息一網(wǎng)打盡
網(wǎng)站介紹 關(guān)于我們 聯(lián)系方式 廣告業(yè)務 幫助信息
1998-2022 ChinaKaoyan.com Network Studio. All Rights Reserved. 滬ICP備12018245號