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分類:導(dǎo)師信息 來(lái)源:中國(guó)考研網(wǎng) 2016-07-13 相關(guān)院校:中國(guó)藥科大學(xué)
楊杰,女,博士,副教授。生于1982年8月。
2000.9—2004.7中國(guó)藥科大學(xué)中藥學(xué)專業(yè)(本科)學(xué)士
2004.9—2009.7中國(guó)藥科大學(xué)生藥學(xué)(碩博連讀)博士
2009.9-至今中國(guó)藥科大學(xué)中藥分析教研室,2012年5月晉升副教授。
一直從事中藥及其制劑的質(zhì)量控制、中藥藥效物質(zhì)基礎(chǔ)等方面的研究。工作3年來(lái),主持國(guó)家自然科學(xué)基金2項(xiàng);江蘇省自然科學(xué)基金、教育部博士點(diǎn)基金等科研項(xiàng)目5項(xiàng),并參與國(guó)家科技重大專項(xiàng)等項(xiàng)目的研究。以第一作者或通訊作者發(fā)表論文10余篇,在中藥現(xiàn)代化研究領(lǐng)域中具有較強(qiáng)的科研積累。
研究方向及相關(guān)課題:
1、現(xiàn)代中藥分析
課題資助:(1)國(guó)家科技重大專項(xiàng):中藥材質(zhì)量標(biāo)準(zhǔn)研究(批準(zhǔn)號(hào):2009ZX09308-04,主要參與者)
2、中藥藥效物質(zhì)基礎(chǔ)及質(zhì)量控制
課題資助:(1)國(guó)家自然科學(xué)基金:翻白草中科羅索酸與所含三萜類成分協(xié)同調(diào)控巨噬細(xì)胞極化穩(wěn)態(tài)系統(tǒng)抗2型糖尿病有效成分群的發(fā)現(xiàn)(批準(zhǔn)號(hào):81102763,主持)
(2)國(guó)家自然科學(xué)基金:丹參地上部位調(diào)控巨噬細(xì)胞極化穩(wěn)態(tài)抗動(dòng)脈粥樣硬化的物質(zhì)基礎(chǔ)及作用機(jī)制研究(批準(zhǔn)號(hào):81373919,主持)
(3)教育部博士點(diǎn)基金:從巨噬細(xì)胞極化途徑探討民間藥物翻白草總萜酮部位抗2型糖尿病的物質(zhì)基礎(chǔ)及作用機(jī)制(批準(zhǔn)號(hào):No.20100096120004,主持)
(4)江蘇省自然科學(xué)基金:山綠茶抗非酒精性脂肪肝有效成分群的發(fā)現(xiàn)及其效應(yīng)機(jī)制(批準(zhǔn)號(hào):BK2011627,主持)
(5)國(guó)家自然科學(xué)基金:不同有效成分群組合效應(yīng)研究山綠茶抗非酒精性脂肪肝藥效物質(zhì)基礎(chǔ)及效應(yīng)成分分析(批準(zhǔn)號(hào):81073039,參與)
(6)中央高校基本科研業(yè)務(wù)費(fèi)專項(xiàng)基金:基于代謝組學(xué)探討山綠茶不同有效成分群抗非酒精性脂肪肝的效應(yīng)關(guān)系及效應(yīng)機(jī)制(批準(zhǔn)號(hào):JKQ2009008,主持)
(7)天然藥物活性組分與藥效國(guó)家重點(diǎn)實(shí)驗(yàn)室優(yōu)秀青年學(xué)者基金:基于多維液質(zhì)聯(lián)用技術(shù)研究山綠茶抗NAFLD有效成分群的體內(nèi)過(guò)程及其資源的發(fā)掘(批準(zhǔn)號(hào):JKGQ201117,主持)
研究成果
1.Hong Chen,Jie Yang (Co- first author), Qin Zhang, Li-Hong Chen, Qiang Wang*. Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression. Circulation Journal. 76(4):995-1003,2012
2.Hong Chen, Qin Zhang, Xiaoming Wang, Jie Yang * (Co-corresponding author) and Qiang Wang*,Qualitative Analysis and Simultaneous Quantification of Phenolic Compounds in the Aerial Parts of Salvia miltiorrhiza by HPLC-DAD and ESI/MSn, Phytochemical Analysis, 22:247-257,2011
3.Jie Yang,Fang Lv, Xiao-qing Chen, Wei-xi Cui, Li-hong Chen, Xiao-dong Wen*, Qiang Wang*, Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/ electrospray ionization mass spectrometry.Journal of pharmaceutical and biomedical analysis 77:21-28,2013.
4.Jie Yang, Xiao-dong Wen, Bei-xi Jia, Qian Mao, Qiang Wang*, Mao-xiang Lai. Quality evaluation of Potentilla discolor by high-performance liquid chromatography coupled with diode detection and electrospray ionization tandem mass spectrometry. Phytochemical Analysis,22(6)547-554,2011
5.Jie Yang, Hong Chen, Li Zhang, Qiang Wang*, Mao-Xiang Lai. Anti-diabetic effect of standardized extract ofPotentilla discolorBungeand identification of its active components. Drug Development Research,71:127-132,2010
6.Rong-Hua Ma, Jie Yang (Co- first author),Lian-Wen Qi, Gui-ZhongXin, Chong-Zhi Wang, Chun-Su Yuan, Xiao-Dong Wen*, Ping Li*. In vivo microdialysis with LC–MS for analysis of spinosin and its interaction with cyclosporin A in rat brain, blood and bile. Journal of Pharmaceutical and Biomedical Analysis, 62: 22-29, 2012
7.Xiao-Dong Wen, Jie Yang (Co- first author), Rong-Hua Ma, Wen Gao, Lian-Wen Qi, Ping Li, Brent A. Bauer, Guang-Jian Du, Zhiyu Zhang, Jacqueline Somogyi, Chong-Zhi Wang, Chun-Su Yuan*, Analysis of Panaxnotoginsengmetabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis sampling, Journal of Chromatography B, 895-896:162-168, 2012.
8.Li Zhang, Jie Yang (Co- first author), Xiao-qing Chen, Zanke, Xiao-dong Wen, Qiang Wang*, Mao-xiang Lai. Antidiabetic and antioxidant effects of extracts from Potentilla discolor Bunge on diabetic rats induced by high fat diet and streptozotocin. Journal of ethnopharmacology, 132(2):518-524,2010
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