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分類:導(dǎo)師信息 來源:中國考研網(wǎng) 2016-07-09 相關(guān)院校:中國藥科大學(xué)
劉建平,1982年畢業(yè)于中國藥科大學(xué)藥學(xué)專業(yè),現(xiàn)為中國藥科大學(xué)藥劑研究所所長、藥劑教研室副主任,藥劑學(xué)博士、教授、博士生導(dǎo)師。1999年赴新西蘭Otago大學(xué)藥學(xué)院進修。
兼任國家食品藥品監(jiān)督管理局保健品審評專家、農(nóng)業(yè)部獸藥審評專家、江蘇省藥劑專業(yè)委員會副主任、江蘇省藥品保健品制劑審評專家、江蘇省九三學(xué)社醫(yī)藥委員會委員等職。
研究方向:生物功能性藥物載體,緩控釋制劑、經(jīng)皮給藥系統(tǒng)、中藥新劑型
主要研究內(nèi)容和成果:利用血漿高密度脂蛋白逆轉(zhuǎn)運膽固醇,具有抗動脈粥樣硬化的性質(zhì)和作用,重組高密度脂蛋白載藥系統(tǒng),達到載體與藥物的協(xié)同治療作用,獲2項國家自然科學(xué)基金項目資助;針對中藥多成分體內(nèi)過程差異較大,不利于發(fā)揮協(xié)同作用的問題,對中藥多成分體內(nèi)過程進行藥動學(xué)與藥效學(xué)的二次調(diào)控與改造,獲1項國家自然科學(xué)基金項目資助。主持科技部“十一五”重大專項、國家中醫(yī)藥管理局項目、江蘇省“六大人才”高峰項目、江蘇省自然科學(xué)基金、江蘇省社會發(fā)展基金等項目項目,負責(zé)或參與科技部“十五”國家科技攻關(guān)、“十一五”國家科技支撐計劃、新西蘭國際合作項目、江蘇省高新技術(shù)招標項目、江蘇省科技基礎(chǔ)設(shè)施建設(shè)計劃-科技公共服務(wù)平臺項目、江蘇省中醫(yī)藥管理局項目以及企業(yè)合作開發(fā)項目等共25項。
通過江蘇省科技廳成果鑒定三項,獲2004年南京市科技進步獎三等獎、2011國家人口和計生委優(yōu)秀科技成果一等獎,申請發(fā)明專利27項,已授權(quán)9項。發(fā)表論文129篇(其中SCI42篇、EI收載2篇)。
近3年發(fā)表的代表性論文(以下均為通訊作者)
1.Post-insertion of poloxamer 188 strengthened liposomal membrane and reduced drug irritancy and in vivo precipitation, superior to PEGylation [J]. Journal of Controlled Release, 2015, 23(10): 161-169.(SCI,7.705)
2.Suppression of Remodeling Behaviors with Arachidonic Acid Modification for Enhanced in vivo Antiatherogenic Efficacies of Lovastatin-loaded Discoidal Recombinant High Density Lipoprotein[J]. Pharmaceutical Research, Published online:04 June 2015.(SCI,3.952)
3.Tanshinone IIA loaded pellets developed for angina chronotherapy: Deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation[J]. European Journal of Pharmaceutical Sciences, 2015, 76(2015): 156–164.(SCI,3.35)
4.Strategies to Maximize Liposomal Drug Loading for a Poorly Water-soluble Anticancer Drug [J]. Pharmaceutical research, 2015, 32(4): 1451-1461. (SCI,3.952)
5.Physicochemical characterization of asulacrine towards the development of an anticancer liposomal formulation via active drug loading: Stability, solubility, lipophilicity and ionization. International Journal of Pharmaceutics, 2014, 473 (1–2), 528–535. (SCI,3.785)
6.Hyaluronic acid-decorated reconstitude high density lipoprotein targeting atherosclerotic lesion [J]. Biomaterials, 2014, 35(27): 8002–8014. (SCI,8.312)
7.Arachidonic Acid-modified Lovastatin Discoidal Reconstituted High Density Lipoprotein Markedly Decrease the Drug Leakage during the Remodeling Behaviors Induced by Lecithin Cholesterol Acyltransferase. Pharmaceutical Research, 2014, 31(7): 1689-1709. ( SCI, 3.952)
8.Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins, Biomaterials, 2013, 34(1):306-319. (SCI, 7.604)
9.Bioavailability and foam cells permeability enhancement of Salvianolic acid B pellets based on drug–phospholipids complex technique. European journal of pharmaceutics and biopharmaceutics, 2013,83(1):76-86. (SCI,3.826)
10.Release Behavior of Tanshinone IIA Sustained-Release Pellets Based on Crack Formation Theory. Journal of pharmaceutical sciences, 2012,101(8):2811-2820. (SCI,3.055)
11.Preparation, Characterizations, and In Vitro Metabolic Processes of Paclitaxel-Loaded Discoidal Recombinant High-Density Lipoproteins. Journal of pharmaceutical science, 2012,101(8):2900-2908. (SCI,3.055)
12.Novel Tanshinone II A ternary solid dispersion pellets prepared by a single-step technique: in vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 2012,80:426-432. (SCI,4.269)
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