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主要從事抗腫瘤和抗代謝性疾病藥物研究，重點開展與性激素代謝紊亂有關(guān)的腫瘤（乳腺癌、子宮內(nèi)膜癌、卵巢癌、前列腺癌等）和老年�。ǜ昶诠琴|(zhì)疏松、良性前列腺增生、血脂異常、II型糖尿病等）治療藥物的研究與開發(fā)；此外，還從事甾體新藥開發(fā)及老品種合成工藝改進、甾體新資源的開發(fā)和利用。

承擔(dān)科研項目：

1.主持國家自然科學(xué)基金面上項目（ER/VEGFR雙靶點抗乳腺癌藥物研究，81373279）；

2.主持科技部“重大新藥創(chuàng)制”科技重大專項（調(diào)血脂候選藥研究，2012ZX09103101-041）；

3.主持江蘇省科技支撐計劃-社會發(fā)展項目（抗乳腺癌藥物研究，BE2012745）；

4.主持江蘇省“六大人才高峰”項目（基于CETP的調(diào)血脂藥物分子發(fā)現(xiàn)及活性研究，2013-YY003）；

5.主持南京市321領(lǐng)軍型科技創(chuàng)業(yè)人才計劃項目：創(chuàng)新藥物及醫(yī)藥中間體研發(fā)及產(chǎn)業(yè)化；

6.主持江蘇省國際合作項目（SERM化合物設(shè)計、合成及生物活性，BZ2008058）；

7.主持國家發(fā)改委西部高技術(shù)產(chǎn)業(yè)化示范工程子項：蕃蔴二烯物合成甾體激素藥物的研究；

8.參加科技部“重大新藥創(chuàng)制”科技重大專項（抗乳腺癌候選藥物，2012ZX09103101-048）；

9.參加國家自然基金重點項目（具有NRF2-Keap1蛋白-蛋白相互調(diào)控作用的類天然產(chǎn)物研究，81230078）。

10.與多家甾體激素制藥企業(yè)合作，主持多項新藥研究項目，作為項目負責(zé)人獲得新藥證書三本，負責(zé)開發(fā)的多個原料藥品種投放生產(chǎn)。

承擔(dān)教學(xué)：

主講課程：高等有機化學(xué)（研究生課程）、藥物化學(xué)（本科生課程）等；

指導(dǎo)博士及碩士研究生學(xué)位論文、本科生畢業(yè)實踐、創(chuàng)新實踐項目、開放性實驗項目等。

近期論文：

1.Xinge Zhao, Minhang Xin, Yazhou Wang, Wei Huang, Qiu Jin, Feng Tang, Gang Wu, Yong Zhao, Hua Xiang*. Discovery of thieno [3,2-c]pyridin-4-amines as novel Bruton’s tyrosine kinase (BTK) inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(17): 6059-6068
2.Wenbin Wang, Yi He, Pei Xu, Qidong You, Hong Xiao, Hua Xiang*. Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities. Bioorganic & Medicinal Chemistry, 2015, 23 (15): 4428-4433
3.Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*. Pyrrolo [2,3-b]pyridine derivatives as potent Bruton’s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(15): 4344-4353
4.Xinge Zhao, Wei Huang, Yazhou Wang, Minhang Xin, Qiu Jin, Jianfeng Cai, Feng Tang, Yong Zhao, Hua Xiang*. Discovery of novel Bruton’s tyrosine kinase (BTK) inhibitors bearing a pyrrolo [2,3-d]pyrimidine scaffold. Bioorganic & Medicinal Chemistry, 2015, 23(4): 891-901
5.Xinge Zhao, Minhang Xin, Wei Huang, Yanliang Ren, Qiu Jin, Feng Tang, Hailong Jiang, Yazhou Wang, Jie Yang, Shifu Mo, Hua Xiang*. Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton’s tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23(2): 348-364
6.Tang ZC, Niu SX, Liu F, Lao KJ, Miao JS, Ji JZ, Wang X, Yan M, Zhang LY, You QD, Xiao H, Xiang H*. Synthesis and biological evaluation of 2, 3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ERα and VEGFR-2. Bioorg Med Chem Lett. 2014, 24(9): 2129-2133
7.Wang L, Zeng Y, Wang T, Liu H, Xiao H, Xiang H*. Evaluating the potential bioactivity of a novel compound ER1626. PLoS One. 2014, 9(1): 1-9
8.Minhang Xin, Ying Gao, Hua Xiang*, Dong Chen, Yi He, Qidong You. A general and facile synthesis of novel polysubstituted quinazolin-4(3H)-ones. Journal of Heterocyclic Chemistry, 2013, 50(1): 169-174
9.Chen D, Yang K, Xiang H*, Jiang S. New ligands for copper-catalyzed C–N coupling reactions with aryl halides. Tetrahedron Lett, 2012; 53:7121-7124
10.Jie Sun, Hua Xiang*, Lila Yang, Jiabao Chen. A Review on Steroidal 5α-Reductase Inhibitors for Treatment of Benign Prostatic Hyperplasia. Current Medicinal Chemistry, 2011, 18 (23): 3576-3589
11.Wei Zhao, Jie Sun, Hua Xiang*, Yanyan Zeng, Xiaobo Li, Hong Xiao, Deying Chen Renling Ma. Synthesis and biological evaluation of new Flavonoid Fatty Acid Esters with anti-adipogenic and enhancing glucose consumption activities. Bioorganic & Medicinal Chemistry. 2011, 19: 3192–3203
12.Jie Jiao, Hua Xiang*, Qingjiang Liao. Recent advancement in nonsteroidal aromatase inhibitors for treatment of estrogen-dependent breast cancer. Current Medicinal Chemistry, 2010, 17 (30): 3476-3487
13..Hua Xiang*, Wei Zhao, Hong Xiao, et al. Synthesis and biological evaluation of Isoflavone Fatty Acid Esters with potential weight loss and hypolipidemic activities. Bioorganic & Medicinal Chemistry, 2010, 18: 3036–3042
14..Minhang Xin, Qidong You, Hua Xiang*. An efficient, practical synthesis of 2-methoxyestradiol. Steroids, 2010, 75 (1) : 53-56
15..Tianlin Wang, Qidong You, Hua Xiang*. Recent Advances in Selective Estrogen Receptor Modulators for Breast Cancer. Mini-review in medicinal chemistry, 2009, 9, 1191-1201

近期專利：

1.Hua Xiang, Tianlin Wang, Hong Xiao, Qidong You，Yao Yao, Xiaobo Li, Qingjiang Liao. Inden[1, 2-b]isoquinolinone derivatives, production and use thereof as a medicament. US8664238 B2. WO 2011047515 A1.（授權(quán)）
2.Hua Xiang, Wei Zhao, Hong Xiao, Yao Yao, Renling Ma, Lei Qian, Xiaobo Li, Qidong You, Qingjiang Liao. Isoflavone Fatty Acid Ester Derivatives, Preparation Methods and Medicinal Uses Thereof. US8846752 B2, WO2011106924 A1.（授權(quán)）
3.向華，勞可靜，唐智超，嚴明，寧珊珊，張陸勇，尤啟冬.4-咪唑基喹啉酮類芳香化酶抑制劑、制備方法和醫(yī)藥用途.ZL201310081971.9（授權(quán)）
4.向華，寧珊珊，劉元元，孫潔，尋國良，嚴明，徐旭東，張陸勇，廖清江，尤啟冬.甾體類5α-還原酶抑制劑、其制備方法及其醫(yī)藥用途.ZL201210001077.1（授權(quán)）
5.向華，王文賓，肖紅等.異黃酮酰胺類衍生物、其制備方法和醫(yī)藥用途.CN201510106301.7
6.向華，牛紹雄，唐智超等；trans-四氫異喹啉酮-4-羧酸衍生物的合成方法與醫(yī)藥用途.CN201510180778.X
7.向華，唐鄭普，駱國順等.香豆雌酚開環(huán)類似物及其醫(yī)藥用途：中國專利，201510113977.9
8.向華,勞可靜,何聰慧,唐鄭普,嚴明,肖紅,尤啟冬.甾體類雄激素受體抑制劑、其制備方法及其醫(yī)藥用途.2014,CN103694299A.
9.向華,劉元元,辛敏行,司文博,林森森,張陸勇.一類作為血管抑制劑的雌甾衍生物、其制備方法和醫(yī)藥用途.2013,CN102952168A.
10.向華，何怡，趙維，肖紅.異黃酮或類黃酮脂肪醚類衍生物、其制備方法和醫(yī)藥用途，CN102964322A
11.向華，司文博，劉元元，嚴明，肖紅，尤啟冬，張陸勇，廖清江.喹唑啉酮類血管抑制劑、其制備方法及其醫(yī)藥用途.CN102875480A.
12.向華，寧珊珊，劉元元，孫潔，尋國良，嚴明，徐旭東，張陸勇，廖清江，尤啟冬.甾體類5α-還原酶抑制劑、其制備方法及其醫(yī)藥用途.CN102532236A
13..向華,趙維，辛敏行，李驍博，陳德英，馬仁玲，廖清江.類黃酮脂肪酸酯類衍生物、其制備方法和醫(yī)藥用途.CN102603685A
14..向華，王天麟，肖紅，尤啟冬，姚瑤，李驍博，廖清江.茚并異喹啉酮衍生物、其制備方法及其醫(yī)藥用途.ZL200910233991.7（授權(quán)）
15.向華，錢磊，趙維，巫冠中，廖清江.大豆黃素脂肪酸酯類衍生物、其制備方法和醫(yī)藥用途.ZL200810156213.8（授權(quán)）

聯(lián)絡(luò)方式：

Tel：025-83271096(Tel/Fax);E-mail：cpuxianghua@163.com

通信地址：南京市童家巷24號，中國藥科大學(xué)藥學(xué)院藥物化學(xué)教研室，郵編210009